nanopartica GmbH / Technology / Advanced

Advanced

nanopartica GmbH technology in more details.

We are producing and selling naotransporters and nanocarrier as such as well as filled nanotransporters with dyes, with metal ions or even metal nanoparticles.

The nanotransporter is built up by hyperbranched polymers and usually we are using dendritic polyglycerol or dendritic polyethyleneimine.

cartoon of a hyperbranched polymer.

To receive the desired properties of the nanotransporter we further functionalize it.This functionalization can be done to change the solubility, to make the nanocarrier less toxic or even more based on application, to make it able to bind to DNA and RNA, to make it carry a higher quantity of metal nanoparticles (our maximum value is 2.8 g/L of gold nanoparticles), to make it bind to dyes or other fluorescent, phosphorescent molecules.

cartoon of functionalized hyperbranched polymer.

Due to the functional groups our nanotransporters are soluble in:

Blood, Serum, PBS buffer, Water, Ethylene Glycol, Methanol, Ethanol, Acetonitrile, DMSO, DMF, Acetone, DCM, Chloroform, Ethyl Acetate, THF and Toluene.

Several chemical molecules, metal ions and metal nanoparticles have already been encapsulated with our nanotransporters:

Nile Red, siRNA, Nimopidin, Methotrexate, Doxorubicin, Congo Red, Vitamine A, Vitamine C, Vitamin B2, Vitamin B6, Vitamin D3, Carotene, Rose Bengal, Gold, Silver, Ruthenium, Platinum, Palladium and Copper.

The above list is not our limitation - it contains what we have already done.

Based on the encapsulated component we receive various properties of which a few is mentioned in our product description.

The encapsulation of the substrates are done in two different ways:

  1. Through the choice of functional groups
  2. Through the agglomeration of several polymer unit

cartoon of the way #1. Gold nanoparticles used as example.

cartoon of way #2. Gold nanoparticles used as example.

These encapsulations are extremely stabile from outside influences. For instance gold nanoparticles are stabile in a pH range from 1 to 14 and in high ionic strength.

Depending on the application the nanotransporter is either destroyed or the encapsulated compound is leaching out to give the specific properties needed for Your application.