nanopartica GmbH / Applications / Drug Formulation and Encapsulation

Drug Formulation and Encapsulation

With our nanotransporters, nanocarriers as well as our amphiphiles we are able to encapsulate highly hydrophobic as well as hydrophilic drugs. One of the tested drugs has been doxorubicin. These nanotransporters and amphiphiles are also useful for the encapsulation of vitamins (A, B2, B6, C & D3 have been tested).

An even easier approach is to use the nanotransporters as well as the amphiphiles directly in the formulation of the tablets since it then have the desired effect of aiding the solubilization of the guest molecules without being forced to completely encapsulate the substance which significantly decreased the capacity that can be loaded.

The benefit with the nanotransporter lies within the increased solubility of extremely hydrophobic drugs, with the release and the EPR (enhanced permeation & retention) effect.

There are two additional effects that must not be forgotten:

One is that these nanocarriers can simply be used in the formulation of the tablet or pill instead of using for instance PEG (very commonly used) which we today know gives a response with the immune system. In this case the hosted molecules does not have to be encapsulated but simply grounded together to improve the solubilisation of the drug / vitamins.

A secondary approach is to use it for carrying vitamins, drugs or other useful molecules into the skin of a person. It has been shown that these nanocarriers are very good in bringing substances deep into the skin layers and can even help to moisturise the skin.

To ensure biocompatibility we are working with our non-toxic dendritic polyglycerol, the double-shell or the non-toxic functionalized dendritic polyethyleneimine.